Development of Adagrasib’s Commercial Manufacturing Route

已完结 10 由大欣发布于 2024/9/18 12:24:56

DOI:10.1021/acs.oprd.2c00386
作者：David R. Snead*,?Yonghong Gan*,?Thomas Scattolin,?Dinesh J. Paymode,?Michal Achmatowicz,?Duane E. Rudisill,?Ephraim S. Vidal,?Tawfik Gharbaoui,?Phil Roberts,?Jianbo Yang,?Zhangbing Shi,?Wei Liu,?Joshu
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：A commercial route to adagrasib (1) was developed to support clinical and commercial needs. Yield was improved to 32% over six chemical steps. A doubly regioselective SNAr reduced consumptio

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