Manufacturing Process Development for Belzutifan, Part 5: A Streamlined Fluorination–Dynamic Kinetic Resolution Process

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DOI:10.1021/acs.oprd.1c00242
文献类型：期刊论文
补充材料：只需要正文
文献链接：https://doi.org/10.1021/acs.oprd.1c00242

American Chemical Society (ACS)

Abstract：Here we report the fluorination–dynamic kinetic resolution (DKR) process for the commercial supply of belzutifan (MK-6482). Key process safety and robustness issues in the Selectfluor fluori

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