Fit-for-Purpose Synthesis of a KRASG12C Covalent Inhibitor, via a Diastereoselective Hayashi Arylation

已完结 10 由胖子发布于 2024/7/27 8:43:27

DOI:10.1021/acs.oprd.4c00211
作者：Carmela Molinaro, Nicholas Wong, Nicholas A. White, Lauren E. Sirois, Raphael Bigler, Quentin P. Bindschaedler, Steven Do, Sushant Malhotra, Francis Gosselin
文献类型：期刊论文
补充材料：只需要正文

American Chemical Society (ACS)

Abstract：An enabling, fit-for-purpose synthesis of stereochemically pure KRASG12C covalent inhibitor 1, a potential new treatment for cancer, is described. The synthetic route provided 1 in 13 steps

应助信息

求助已完结，文件已删除 如有需求请重新发布求助一键发布

感谢使用Book学术
本站所有文献仅供个人学习和参考，请勿将文件进行传播。共同遵守网站规定和相关知识产权规定。

上一个求助:其它数据库Naturally Fractured Carbonate Reservoir Characterization: A Case Study of a Mature High-Pour Point Oil Field in Hungary 下一个求助:其它数据库Cognitive Limitations in Driving: How Perception and Information Processing Affect Driving Performance