Scalable Synthesis of ABBV-105 Enabled by Suzuki Coupling with Low Pd Loading, Ru-Catalyzed Asymmetric Hydrogenation, and Acylation Using Impinging Jet

已完结 10 由小太阳发布于 2024/7/26 8:51:26

DOI:10.1021/acs.oprd.4c00117
作者：Benoit Cardinal-David, Shashank Shekhar, Eric M. Phillips, Elizabeth C. Swift, Brian Kotecki, Andrew R. Ickes, Gregory E. Storer, Daniel D. Caspi, Anuj Verma, Eric G. Moschetta, Daniel Tao, Westin H. Morrill, John R. Bellettini, Fredrik L. Nordstrom, Alessandra Mattei, Kirsten Springer, Haixiao Qiu, Jeffrey T. Bien, Onkar Manjrekar, Rodger F. Henry, Grier A. Wallace, Lisa Schaffter, Eric A. Voight
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Evolution of a synthetic process to prepare ABBV-105, a Bruton’s tyrosine kinase (BTK)-inhibitor, on multikilogram scale is described. The first-generation route utilized chiral resolution o

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