Design, synthesis and biological evaluation of purine-based derivatives as novel JAK2/BRD4(BD2) dual target inhibitors

已完结 10 由立秋发布于 2024/8/5 18:38:32

DOI:10.1016/j.bioorg.2023.106386
作者：Yong Guo , Yurong Zou , Yong Chen , Dexin Deng , Zihao Zhang , Kongjun Liu , Minghai Tang , Tao Yang , Suhong Fu , Chufeng Zhang , Wenting Si , Ziyan Ma , Shunjie Zhang , Bin Peng , Dingguo Xu , Lijuan Chen
文献类型：期刊论文
补充材料：只需要正文

Elsevier

Abstract：Based on the pharmacological synergy of JAK2 and BRD4 in the NF-κB pathway and positive therapeutic effect of combination of JAK2 and BRD4 inhibitors in treating MPN and inflammation. A seri

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