Biocatalytic Asymmetric Reduction of a Sterically Hindered α-Bromo Ketone for the Synthesis of Key Intermediates of Olodaterol

已完结 10 由小太阳发布于 2024/8/5 15:56:07

DOI:10.1021/acs.oprd.2c00371
作者：Yahui Feng, Zihong Zhou, Shuming Wu, Wei Lin, Songquan Lu, Xiaolei Pang, Ke Xia, Fang He, Qin Zhang, Hu Yang and Zhongqing Wang*,
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：An efficient and selective biocatalytic process was developed for the reduction of highly bulky and hydrophobic α-bromo ketone 4a using ketoreductase from Lactobacillus kefiri. A fter the in

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