Development of a Cost-Efficient Process Toward a Key Synthetic Intermediate of the EZH2 Inhibitor PF-06821497

已完结 10 由小太阳发布于 2024/8/5 15:51:30

DOI:10.1021/acs.oprd.3c00477
作者：Christopher P. Ashcroft, Alexander M. Berne, Florian Blasberg, Kelly Catlin, Michael R. Collins, Doug J. Critcher, Jean-Nicolas Desrosiers*, Adam Goetz, Cheryl Hayward, Ricky A. Jones, Michael J. Karmilowicz, Nandell Keene, Carlos A. Martinez, Sebastien Monfette, Sebastian David Pattavina, Hahdi H. Perfect, John A. Ragan, Blake Rauschenberger*, Neal W. Sach, Gemma Scotney, Scott C. Sutton, Courtney Talicska, Steven J.R. Twiddle, Jared Van Haitsma and Richard Wisdom,
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：A cost-efficient approach for the synthesis of a key intermediate of the EZH2 inhibitor PF-06821497 was identified after performing process chemistry development. A wide route scouting effor

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