Discovery and Process Development of a Scalable Biocatalytic Kinetic Resolution toward Synthesis of a Sterically Hindered Chiral Ketone

已完结 10 由小太阳发布于 2024/8/5 16:16:26

DOI:10.1021/acs.oprd.2c00067
作者：Nicole Wamser, Hao Wu*, Frederic Buono, Anthony Brundage, Francesco Ricci, Jon C. Lorenz, Jun Wang, Nizar Haddad, Joshua Paolillo, Joyce C. Leung, Heewon Lee and Azad Hossain,
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Sterically hindered chiral ketones are useful intermediates in the synthesis of active pharmaceutical ingredients. Here, we report a scalable and highly enantioselective synthesis through a

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