Identification of the Clinical Candidate PF-07284890 (ARRY-461), a Highly Potent and Brain Penetrant BRAF Inhibitor for the Treatment of Cancer.

已完结 10 由杨小木发布于 2024/8/16 12:01:43

DOI:10.1021/acs.jmedchem.4c00998
作者：Li Ren, David Moreno, Brian R Baer, Patrick Barbour, Tanna Bettendorf, Karyn Bouhana, Karin Brown, Suzy A Brown, Jay B Fell, Dylan P Hartley, Erik J Hicken, Ellen R Laird, Patrice Lee, Joseph McCown, Jennifer N Otten, Brett Prigaro, Ross Wallace, Dean Kahn
文献类型：期刊论文
补充材料：只需要正文

American Chemical Society (ACS)

Abstract：Mutant BRAFV600E is one of the most common oncogenic drivers in metastatic melanoma. While first generation BRAFV600E inhibitors are capable of controlling tumors systemically, they are unab

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