Discovery of Potent, Dual-Inhibitors of Diacylglycerol Kinases Alpha and Zeta Guided by Phenotypic Optimization

已完结 10 由 xx 发布于 2024/8/14 8:53:35

DOI:10.1021/acsmedchemlett.3c00063
作者：Louis Chupak*, Michael Wichroski, Xiaofan Zheng, Min Ding, Scott Martin, Christopher Allard, Jianliang Shi, Robert Gentles, Nicholas A. Meanwell, Jie Fang, Daniel Tenney, John Tokarski, Carolyn Cao and Susan Wee,
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：We describe a phenotypic screening and optimization strategy to discover compounds that block intracellular checkpoint signaling in T-cells. We identified dual DGKα and ζ inhibitors notwiths

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