Synthetic Development and Scale-Up of a Complex Pyrazole Fragment of Lenacapavir

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DOI:10.1021/acs.oprd.4c00235
作者：Nathaniel Kadunce, Olivier St-Jean, Amy Cagulada, Wen-Tau T. Chang, Alexander F. G. Goldberg, Zilin Huang, Jihun Kang, Jinsik Kim, Kyoungchan Kwon, Olga Lapina, Lennie Lin, Trevor J. Rainey, Lyubov Ro
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：We describe herein the process development and scale-up of a complex cyclopropyl pyrazole fragment of lenacapavir, a drug recently approved for long-acting treatment of HIV (Sunlenca). A ten

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