Axial Chirality in the Sotorasib Drug Substance, Part 1: Development of a Classical Resolution to Prepare an Atropisomerically Pure Sotorasib Intermediate

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DOI: 10.1021/acs.oprd.2c00176
文献类型：期刊论文
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文献链接：https://doi.org/10.1021/acs.oprd.2c00176

American Chemical Society (ACS)

Abstract：Described herein is the discovery and development of a process to prepare an atropisomeric intermediate in the synthesis of the KRAS G12C inhibitor sotorasib. Using high-throughput experimen

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