Route Design and Scale-Up of a Topoisomerase I Inhibitor Antibody–Drug Conjugate Payload

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DOI:10.1021/acs.oprd.4c00175
文献类型：期刊论文
补充材料：只需要正文
文献链接：https://doi.org/10.1021/acs.oprd.4c00175

American Chemical Society (ACS)

Abstract：AstraZeneca is currently developing an antibody–drug conjugate for the treatment of cancer with a topoisomerase I inhibitor payload. The drug portion of the molecule is an analogue of the na

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