Discovery of BIO-8169─A Highly Potent, Selective, and Brain-Penetrant IRAK4 Inhibitor for the Treatment of Neuroinflammation

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DOI:10.1021/acs.jmedchem.4c00560
作者：Magnus Pfaffenbach*, Philippe N. Bolduc, Zhili Xin, Fang Gao, Ryan Evans, Terry Fang, Jayanth V. Chodaparambil, Kate L. Henry, Pei Li, Steven Mathieu,&nbsp
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American Chemical Society (ACS)

Abstract：Interleukin receptor associated kinase 4 (IRAK4) plays an important role in innate immune signaling through Toll-like and interleukin-1 receptors and represents an attractive target for the

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