PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models

已完结 10 由陌上花开发布于 2024/10/11 13:16:20

DOI:10.1021/acs.jmedchem.3c01781
作者：Michael Berlin*,?Jennifer Cantley,?Mark Bookbinder,?Elizabeth Bortolon,?Fabio Broccatelli,?Greg Cadelina,?Emily W. Chan,?Huifen Chen,?Xin Chen,?Yunxing Cheng,?Tommy K. Cheung,?Kim Davenport,?Dean DiNi
文献类型：期刊论文
补充材料：只需要正文

American Chemical Society (ACS)

Abstract：The identification of VHL-binding proteolysis targeting chimeras (PROTACs) that potently degrade the BRM protein (also known as SMARCA2) in SW1573 cell-based experiments is described. These

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