An unprecedented free radical mechanism for the formation of DNA adducts by the carcinogenic N-sulfonated metabolite of aristolochic acids

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DOI:10.1016/j.freeradbiomed.2023.05.005
作者：Pei-Lin Li ,&nbsp;Chun-Hua Huang ,&nbsp;Li Mao ,&nbsp;Jun Li ,&nbsp;Zhi-Guo Sheng ,&nbsp;Ben-Zhan Zhu
文献类型：期刊论文
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Elsevier

Abstract：The carcinogenicity of aristolochic acids (AAs) has been attributed mainly to the formation of stable DNA-aristolactam (DNA-AL) adducts by its reactive N-sulfonated metabolite N-sulfonatooxy

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