CAR T cells engineered to secrete IFN-κ induce tumor ferroptosis via an IFNAR/STAT1/ACSL4 axis.

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DOI:10.1158/2326-6066.CIR-24-0130
作者：Yaoxin Gao,?Shasha Liu,?Yifan Huang,?Hui Wang,?Yuyu Zhao,?Xuyang Cui,?Yajing Peng,?Feng Li,?Yi Zhang
文献类型：期刊论文
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Abstract：Ferroptosis is an iron-dependent form of cell death that influences cancer immunity. Therapeutic modulation of ferroptosis is considered a potential strategy to enhance the efficacy of other

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