Multicomponent Synthesis of Imidazole-Based Ionizable Lipids for Highly Efficient and Spleen-Selective Messenger RNA Delivery

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DOI:10.1021/jacs.4c00451
作者：Wang Dong,?Zhibin Li,?Tailin Hou,?Yanqiong Shen,?Zixuan Guo,?Yi-Tan Su,?Ziqi Chen,?Huimin Pan,?Wei Jiang* and Yucai Wang*,?
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：The spleen emerges as a pivotal target for mRNA delivery, prompting a continual quest for specialized and efficient lipid nanoparticles (LNPs) designed to enhance spleen-selective transfecti

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