Design of a Lead-Like Cysteine-Targeting Covalent Library and the Identification of Hits to Cys55 of Bfl-1

已完结 10 由 666888 发布于 2024/11/4 14:28:25

DOI:10.1021/acs.jmedchem.4c00781
作者：Simon C. C. Lucas*,&nbsp;Alexander G. Milbradt,&nbsp;J. Henry Blackwell,&nbsp;Silvia Bonomo,&nbsp;Andrew Brierley,&nbsp;Doyle J. Cassar,&nbsp;Jared Freeman,&nbsp;Thomas E.
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Covalent hit identification is a viable approach to identify chemical starting points against difficult-to-drug targets. While most researchers screen libraries of 2k electrophilic fragments

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