Most azole resistance mutations in the Candida albicans drug target confer cross-resistance without intrinsic fitness cost

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DOI:10.1038/s41564-024-01819-2
作者：Camille Bédard, Isabelle Gagnon-Arsenault, Jonathan Boisvert, Samuel Plante, Alexandre K. Dubé, Alicia Pageau, Anna Fijarczyk, Jehoshua Sharma, Laetitia Maroc, Rebecca S. Shapiro, Christian R. Landr
文献类型：期刊论文
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Nature

Abstract：Azole antifungals are the main drugs used to treat fungal infections. Amino acid substitutions in the drug target Erg11 (Cyp51) are a common resistance mechanism in pathogenic yeasts. How ma

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