Fragment-based Scaffold Hopping: Identification of Potent, Selective, and Highly Soluble Bromo and Extra Terminal Domain (BET) Second Bromodomain (BD2) Inhibitors

已完结 10 由龙行天下发布于 2024/1/31 17:05:09

DOI:10.1021/acs.jmedchem.1c00365
文献类型：学位论文
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American Chemical Society (ACS)

Abstract：The profound efficacy of pan-BET inhibitors is well documented, but these epigenetic agents have shown pharmacology-driven toxicity in oncology clinical trials. The opportunity to identify i

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