Early Process Development of PF-07054894, a Squaramide-Based Antagonist of C–C Chemokine Receptor Type 6 (CCR6)

已完结 10 由春风吹发布于 2024/2/6 16:14:05

DOI:10.1021/acs.oprd.3c00451
作者：Gary M. Chinigo, Emma L. McInturff, Scott W. Bagley, Richard W. Barnhart, David C. Blakemore, Lu Han, Taegyo Lee, Javier Magano, J. Christopher McWilliams, Sebastien Monfette, James J. Mousseau, Senliang Pan, Dylan Pedro, Hahdi H. Perfect, Jeffrey W. Raggon, Peter R. Rose, John Sagal, John I. Trujillo, Jared Van Haitsma, Michael G. Vetelino, Xiaojing Helen Yang
文献类型：期刊论文
补充材料：只需要正文

American Chemical Society (ACS)

Abstract：The original synthesis of a CCR6 antagonist and subsequent enablement for kilogram manufacture is presented. Highlighted improvements made in the preparation for the scale-up campaign includ

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