Rational Design of Benzobisheterocycle Metallo-β-Lactamase Inhibitors: A Tricyclic Scaffold Enhances Potency against Target Enzymes.

已完结 10 由 phoebe9203 发布于 2024/3/1 11:13:52

DOI:10.1021/acs.jmedchem.3c02209
作者：Valentina Villamil, Maria-Agustina Rossi, Maria F Mojica, Philip Hinchliffe, Verónica Martínez, Valerie Castillo, Cecilia Saiz, Claudia Banchio, Mario A Macías, James Spencer, Robert A Bonomo, Alejandro Vila, Diego M Moreno, Graciela Mahler
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Antimicrobial resistance is a global public health threat. Metallo-β-lactamases (MBLs) inactivate β-lactam antibiotics, including carbapenems, are disseminating among Gram-negative bacteria,

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