Kinetic and Mechanistic Investigations to Enable a Key Suzuki Coupling for Sotorasib Manufacture─What a Difference a Base Makes

已完结 10 由小太阳发布于 2024/2/23 19:17:55

DOI:10.1021/acs.oprd.2c00332
作者：James I. Murray*, Liang Zhang*, Adam Simon, Maria V. Silva Elipe, Carolyn S. Wei, Seb Caille and Andrew T. Parsons, 
文献类型：期刊论文
补充材料：只需要正文

American Chemical Society (ACS)

Abstract：The process to manufacture sotorasib (AMG 510) employs a Suzuki–Miyaura reaction as a key step in the synthetic sequence. Detailed kinetic and mechanistic investigations into this process we

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