Combinatorial Screening of Biscarbamate Ionizable Lipids Identifies a Low Reactogenicity Lipid for Lipid Nanoparticle mRNA Delivery

已完结 10 由 1236544 发布于 2024/3/6 12:01:23

DOI:10.1002/adfm.202310623
作者：Emily De Lombaerde, Yong Chen, Tingting Ye, Julie Deckers, Giulia Mencarelli, Kim De Swarte, Heleen Lauwers, Ruben De Coen, Sabah Kasmi, Sanne Bevers, Anna Kuchmiy, Bram Bogaert, Lies Baekens, Zifu Zhong, Alexander Lamoot, Niek N Sanders, Bart N Lambrecht, Antonio P. Baptista, S. de Koker, Bruno G. De Geest
文献类型：期刊论文
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Abstract：Messenger RNA (mRNA) has emerged as a promising therapeutic modality for various diseases. However, efficient delivery of mRNA into target cells remains a significant challenge. In this stud

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