Development and Nanoparticle-Mediated Delivery of Novel MDM2/MDM4 Heterodimer Peptide Inhibitors to Enhance 5-Fluorouracil Nucleolar Stress in Colorectal Cancer Cells

已完结 10 由 Lian 发布于 2024/3/3 22:33:24

DOI:10.1021/acs.jmedchem.3c01312
作者：Francesco Merlino, Annalisa Pecoraro, Giuseppe Longobardi, Greta Donati, Francesco Saverio Di Leva, Chiara Brignola, Rebecca Piccarducci, Simona Daniele, Claudia Martini, Luciana Marinelli, Giulia Russo, Fabiana Quaglia, Claudia Conte*, Annapina Russo* and Valeria La Pietra*, 
文献类型：期刊论文
补充材料：只需要正文

American Chemical Society (ACS)

Abstract：Colorectal cancer (CRC) often involves wild-type p53 inactivation by MDM2 and MDM4 overexpression, promoting tumor progression and resistance to 5-fluoruracil (5-FU). Disrupting the MDM2/4 h

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