A Chiral Pool Strategy for the Synthesis of a SMARCA2 Degrading PROTAC

已完结 10 由小太阳发布于 2024/3/23 10:08:03

DOI:10.1021/acs.oprd.4c00048
作者：Miseon Lee, Jiang-Ping Wu, Jaehee Lee, Jun Wang, Jada A. H. White, Kyle W. Rugg, Alexander Sienkiewicz, Jon C. Lorenz, Peter Greb, Matthew H. Bunner, David A. Hirsh, Nina C. Gonnella, Fredrik L. Nordstrom, Christiane Kofink, Harald Weinstabl, Jonathan T. Reeves
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：A scalable synthesis of the SMARCA2 degrading PROTAC 1 was developed. The linker fragment was derived from (S)-citronellol by oxidative cleavage and diastereoselective aryl Grignard addition

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