The molecular glue CLEO4-88 inhibits the ACAA1 thiolase by induced binding to GID4.

已完结 10 由 CSJ 发布于 2026/4/26 18:52:49

DOI:10.1038/s41589-026-02183-4
作者：Chetan K Chana,Ines Ben Makhlouf,Jaeyoun Kim,April J Y Yu,Nathalie Moatti,Stephen Orlicky,Cassandra J Wong,Leon Baronijan,XiaoJing Tang,Daniel Mao,Brett Larsen,Laura McGary,Brendon Seale,Pavel Mader,D
文献类型：期刊论文
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Nature

Abstract：Molecular glues promote protein-protein interactions by enhancing the surface complementarity between proteins. Those that recruit an E3 ubiquitin ligase to a target can elicit ubiquitinatio

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