Selective Replacement of Cholesterol with Cationic Amphiphilic Drugs Enables the Design of Lipid Nanoparticles with Improved RNA Delivery

已完结 10 由 1236544 发布于 2024/6/11 17:22:30

DOI:10.1021/acs.nanolett.3c03345
作者：Bram Bogaert, Aliona Debisschop, Thomas Ehouarne, Hannelore P. Van Eeckhoutte, Joyceline De Volder, An Jacobs, Eline Pottie, Riet De Rycke, Aurélie Crabbé, Pieter Mestdagh, Ine Lentacker, Guy G. Brusselle, Christophe Stove, Sandra Verstraelen, Tania Maes, Ken R. Bracke, Stefaan C. De Smedt and Koen Raemdonck*,
文献类型：期刊论文
补充材料：只需要正文

American Chemical Society (ACS)

Abstract：The delivery of RNA across biological barriers can be achieved by encapsulation in lipid nanoparticles (LNPs). Cationic amphiphilic drugs (CADs) are pharmacologically diverse compounds with

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