Process Development of a Tricyclic Diazepine-Based IDH1 Mutant Inhibitor

已完结 10 由胖子发布于 2024/6/8 21:25:37

DOI:10.1021/acs.oprd.4c00171
作者：Matthew L. Maddess, Ed Cleator, Mariko Morimoto, Adrian Goodyear, Alejandro Dieguez-Vazquez, Andrew Gibb, Andy Kirtley, Melodie Christensen, Chaohui Song, Feng Peng, Mahbub Alam, Stephen P. Keen, Steven F. Oliver
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Process development to improve synthetic access to a potent, selective, and brain-penetrant tricyclic diazepine clinical candidate that inhibits mutant IDH1 is described. A variety of discon

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