Discovery and Optimization of Orally Bioavailable Phthalazone and Cinnolone Carboxylic Acid Derivatives as S1P2 Antagonists against Fibrotic Diseases

已完结 10 由咸鱼发布于 2024/6/6 9:32:05

DOI:10.1021/acs.jmedchem.1c01066
作者：Oscar Mammoliti*, Koen Jansen, Sandy El Bkassiny, Adeline Palisse, Nicolas Triballeau, Denis Bucher, Brigitte Allart, Alex Jaunet, Giovanni Tricarico, Maxim De Wachter, Christel Menet, Javier Blanc, Vatroslav Letfus, Renata Rupčić, Mario Šmehil, Tanja Poljak, Beatrice Coornaert, Kathleen Sonck, Inge Duys, Ludovic Waeckel, Lola Lecru, Florence Marsais, Catherine Jagerschmidt, Marielle Auberval, Philippe Pujuguet, Line Oste, Monica Borgonovi, Emanuelle Wakselman, Thierry Christophe, Nicolas Houvenaghel, Mia Jans, Bertrand Heckmann, Laurent Sanière, Reginald Brys
文献类型：期刊论文
补充材料：只需要正文

American Chemical Society (ACS)

Abstract：Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease. Current treatments only slow down disease progression, making new therapeutic strategies compelling. Increasing

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