Synthesis of Nirmatrelvir: Development of a Scalable Cobalt-Catalyzed Cyclopropanation for Manufacture of the Bicyclic [3.1.0]Proline-Building Block

已完结 10 由万神发布于 2024/6/12 9:05:31

DOI:10.1021/ACS.OPRD.3C00251
文献类型：期刊论文
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文献链接：https://doi.org/10.1021/acs.oprd.3c00251

American Chemical Society (ACS)

Abstract：Nirmatrelvir is a potent, selective, and orally bioavailable inhibitor of SARS-CoV-2 Mpro. Herein, we report a scalable cyclopropanation to produce the bicyclic [3.1.0]proline derivative, wh

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