A Chiral Pool Strategy for the Synthesis of a SMARCA2 Degrading PROTAC

已完结 10 由万神发布于 2024/7/1 9:05:37

DOI:10.1021/acs.oprd.4c00048
文献类型：期刊论文
补充材料：只需要正文
文献链接：https://doi.org/10.1021/acs.oprd.4c00048

American Chemical Society (ACS)

Abstract：A scalable synthesis of the SMARCA2 degrading PROTAC 1 was developed. The linker fragment was derived from (S)-citronellol by oxidative cleavage and diastereoselective aryl Grignard addition

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