Discovery and Pharmacological Characterization of Novel Quinazoline-Based PI3K Delta-Selective Inhibitors

已完结 10 由杨小木发布于 2024/7/7 13:20:57

DOI:10.1021/acsmedchemlett.6b00119
文献类型：期刊论文
补充材料：只需要正文
文献链接：https://doi.org/10.1021/acsmedchemlett.6b00119

American Chemical Society (ACS)

Abstract：Inhibition of the lipid kinase PI3Kδ is a promising principle to treat B and T cell driven inflammatory diseases. Using a scaffold deconstruction–reconstruction strategy, we identified 4-ary

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