Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M4 Muscarinic Acetylcholine Receptor

已完结 10 由杨小木发布于 2024/7/5 10:35:50

DOI:10.1021/acs.jmedchem.4c00293
作者：Christopher R. Butler, Michael Popiolek, Laura A. McAllister, Erik A. LaChapelle, Melissa Kramer, Elizabeth M. Beck, Scot Mente, Michael A. Brodney, Matthew Brown, Adam Gilbert, Chris Helal, Kevin Ogilvie, Jeremy Starr, Daniel Uccello, Sarah Grimwood, Jeremy Edgerton, Jonathan Garst-Orozko, Rouba Kozak, Susan Lotarski, Amie Rossi, Deborah Smith, Rebecca O’Connor, John Lazzaro, Claire Steppan, Stefanus J. Steyn
文献类型：期刊论文
补充材料：只需要正文

American Chemical Society (ACS)

Abstract：Selective activation of the M4 muscarinic acetylcholine receptor subtype offers a novel strategy for the treatment of psychosis in multiple neurological disorders. Although the development o

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