Scalable Synthesis of C5aR1 Antagonist ACT-1014-6470 via N7-Selective Reductive Amination of an Unprotected Pyrazole Starting Material and Intramolecular Urea Formation with 1,1′-Carbonyl-di(1,2,4-triazol) (CDT)

已完结 10 由小太阳发布于 2024/4/12 8:31:53

DOI:10.1021/acs.oprd.3c00492
作者：Stefan Reber, Nicole Blumer, Daniel Leuenberger, Tony Fleischer, Dorte Renneberg, Stefan Abele, Gabriel Schäfer
文献类型：期刊论文
补充材料：只需要正文

American Chemical Society (ACS)

Abstract：ACT-1014-6470 is a potent, orally available, reversible, and selective C5aR1 antagonist. Herein, we report the development of a scalable and robust process for the preparation of ACT-1014-64

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