Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor

已完结 10 由 jxxjxx 发布于 2024/4/9 23:18:55

DOI:10.1016/j.ejmech.2021.113776
文献类型：期刊论文
补充材料：只需要正文
文献链接：https://doi.org/10.1016/j.ejmech.2021.113776

Elsevier

Abstract：FMS-like tyrosine kinase 3 (FLT3) with an internal tandem duplication (ITD) mutation has been validated as a driver lesion and a therapeutic target for acute myeloid leukemia (AML). Currentl

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