Cannabinoformins: Designing Biguanide-Embedded, Orally Available, Peripherally Selective Cannabinoid-1 Receptor Antagonists for Metabolic Syndrome Disorders

已完结 10 由龙行天下发布于 2024/4/22 10:42:35

DOI:10.1021/acs.jmedchem.3c00599
作者：Szabolcs Dvorácskó, Alexa Herrerias, Anna Oliverio, Pinaki Bhattacharjee, Lenny Pommerolle, Ziyi Liu, Dechun Feng, Yong-Sok Lee, Sergio A. Hassan, Grzegorz Godlewski, Resat Cinar* and Malliga R. Iyer*,
文献类型：期刊论文
补充材料：只需要正文

American Chemical Society (ACS)

Abstract：We have designed orally bioavailable, non-brain-penetrant antagonists of the cannabinoid-1 receptor (CB1R) with a built-in biguanide sensor to mimic 5'-adenosine monophosphate kinase (AMPK)

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