Age-dependent Lamin changes induce cardiac dysfunction via dysregulation of cardiac transcriptional programs

已完结 10 由小陈发布于 2024/4/16 21:10:32

DOI:10.1038/s43587-022-00323-8
作者：Natalie J. Kirkland, Scott H. Skalak, Alexander J. Whitehead, James D. Hocker, Pranjali Beri, Geo Vogler, Bill Hum, Mingyi Wang, Edward G. Lakatta, Bing Ren, Rolf Bodmer, Adam J. Engler
文献类型：期刊论文
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Nature

Abstract：As we age, structural changes contribute to progressive decline in organ function, which in the heart act through poorly characterized mechanisms. Taking advantage of the short lifespan and

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