The Discovery of Exarafenib (KIN-2787): Overcoming the Challenges of Pan-RAF Kinase Inhibition

已完结 10 由立秋发布于 2024/5/11 17:37:26

DOI:10.1021/acs.jmedchem.3c01830
作者：Young K. Chen*, Toufike Kanouni, Lee D. Arnold, Jason M. Cox, Elisabeth Gardiner, Kathryn Grandinetti, Ping Jiang, Stephen W. Kaldor, Catherine Lee, Chun Li, Eric S. Martin, Nichol Miller, Eric A. Murphy, Noel Timple, John S. Tyhonas, Angie Vassar, Tim S. Wang, Richard Williams, Ding Yuan and Robert S. Kania*,
文献类型：期刊论文
补充材料：只需要正文

American Chemical Society (ACS)

Abstract：RAF, a core signaling component of the MAPK kinase cascade, is often mutated in various cancers, including melanoma, lung, and colorectal cancers. The approved inhibitors were focused on tar

应助信息

2024-05-11

heqiang

该信息应助已超过48小时，文件已经删除。如有需求，请重新发布求助。一键发布

2024-05-11

Book学术机器人

2024/5/11 17:37:26 未找到该文献，机器人已退出，请等待人工下载

2024/5/11 17:37:26 Book学术AI机器人收到请求，开始寻找文献

2024/5/11 17:37:26 已向机器人发送请求

2024-05-11

立秋发布求助

上一个求助:其它数据库Naturally Fractured Carbonate Reservoir Characterization: A Case Study of a Mature High-Pour Point Oil Field in Hungary 下一个求助:WileyK2S2O8-Mediated Efficient Oxidative Deoximation of Flavonoid Oximes under Mild Reaction Conditions