A logic-gated trispecific engager enhances macrophage killing of cancer cells in solid tumors.

已完结 10 由和煦发布于 2026/5/5 17:14:49

DOI:10.1038/s41587-026-03057-9
作者：Xiaotian Zhao,Weiqiang Jing,Ganyu Wang,Zhanyan Liu,Xinxin Xu,Maosen Han,Zhipeng Fu,Yulin Zhang,Zuolin Zheng,Jing Zhang,Longyu Bo,Xianghui Dong,Caiping Li,Yanhua Sun,Junfeng Zhang,Fabao Zhao,Nianzeng X
文献类型：期刊论文
补充材料：只需要正文

Nature

Abstract：The antitumor efficacy of immune cell engagers that bind two targets on the same immune cell is limited by structural constraints, leading to incomplete coengagement and uncoordinated signal

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