Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase

已完结 10 由龙行天下发布于 2024/6/3 15:29:01

DOI:10.1021/acs.jmedchem.2c00902
作者：You Wang, Feng Xu, Connie B. Nichols, Yuqian Shi, Homme W. Hellinga, J. Andrew Alspaugh, Mark D. Distefano and Lorena S. Beese*,
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Infections by fungal pathogens are difficult to treat due to a paucity of antifungals and emerging resistances. Next-generation antifungals therefore are needed urgently. We have developed c

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