Lactylation fuels nucleotide biosynthesis and facilitates deuterium metabolic imaging of tumor proliferation in preclinical models of H3K27M-mutant gliomas

已完结 10 由祁茵发布于 2026/5/5 9:27:12

DOI:10.1126/scitranslmed.adw0834
作者：Georgios Batsios, Céline Taglang, Suresh Udutha, Anne Marie Gillespie, Timothy Phoenix, Sabine Mueller, Sriram Venneti, Carl Koschmann, Pavithra Viswanath
文献类型：期刊论文
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American Association for the Advancement of Science (AAAS)

Abstract：Hyperactivation of glucose metabolism to lactate is a metabolic hallmark of cancer. However, the functional role of lactate in pediatric diffuse midline glioma (DMG) cells is unclear. Here,

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