Initial Route Scouting and Final Process Development for the Multi-Kg Production of 3-Fluoro-6-methoxyquinoline from p-Anisidine and 2-Fluoromalonic Acid

已完结 10 由小太阳发布于 2024/5/28 13:01:26

DOI:10.1021/acs.oprd.1c00414
作者：Gabriel Schäfer*, Tony Fleischer, Nicole Blumer, Megan Udry, Stefan Reber, Ian Stansfield, Yuanhua Liu, Yan Li, Pixu Li
文献类型：期刊论文
补充材料：只需要正文

American Chemical Society (ACS)

Abstract：A scalable route to 3-fluoro-6-methoxyquinoline needed to be developed as multi-kg amounts of this heterocycle were required. Initial route development focused on the formation of the key C–

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