Structure-activity relationship study of HIF-2α inhibitors with tricyclic scaffold

待确认 10 由 Luke 发布于 2026/5/15 14:18:36

DOI:10.1016/j.bmcl.2025.130366
作者：Zhijie Wu,?Changwei Chen,?Jian Yan,?Peipei Zhu,?Min Xiong,?Dong Liu,?Shaojiang Deng
文献类型：期刊论文
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Elsevier

Abstract：HIF-2α is a member of the HIF transcription factor family and a key oncogenic driver in renal cell carcinoma, which is characterized by the overaccumulation of HIF-2α protein. Therefore, inh

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