Tumor-derived branched-chain α-keto acids activate Notch signaling in tumor-associated macrophages to limit immunity.

已完结 20 由尼格买提发布于 2026/5/3 13:23:52

DOI:10.1038/s41590-026-02484-9
作者：Qi-Xiang Ma,Ru Zhao,Jiang-Xue Han,Wen-Ying Zhu,Mi-Die Xu,Xiao-Yan Zhang,Guo-Quan Yan,Wen-Yu Wen,Guang-Chun Han,Min Luo,Miao Yin,Jin-Tao Li,Qun-Ying Lei
文献类型：期刊论文
补充材料：只需要正文
文献链接：https://doi.org/10.1038/s41590-026-02484-9

Nature

Abstract：Tumor cells are highly dependent on branched-chain amino acids, which can activate mechanistic target of rapamycin complex 1, but the downstream catabolite branched-chain α-keto acids (BCKAs

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