Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists

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DOI:10.1126/science.adp1779
作者：Matthias Gl?gl,?Aditya Krishnakumar,?Robert J. Ragotte,?Inna Goreshnik,?Brian Coventry,?Asim K. Bera,?Alex Kang,?Emily Joyce,?Green Ahn,?Buwei Huang,?Wei Yang,?Wei Chen,?Mariana Garcia Sanchez,?Brian
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American Association for the Advancement of Science (AAAS)

Abstract：Despite progress in designing protein-binding proteins, the shape matching of designs to targets is lower than in many native protein complexes, and design efforts have failed for the tumor

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