DMPK Considerations for the Development of Covalent Drugs: Insights from an IQ Assessment

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DOI:10.1021/acs.jmedchem.6c00214
作者：Julian Dopstadt, Kamelia Behnia, Xiaoming Cui, Nicola Colclough, Martin Dowty, Julius Enoru, Robert S. Foti, Felix Huth, Frank Jacobs, Rohitash Jamwal, Benjamin M. Johnson, Shyam Kamble, Julie Lade, S
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American Chemical Society (ACS)

Abstract：Targeted covalent inhibitors (TCIs) are low-molecular-weight drugs containing a reactive warhead to inactivate target proteins. In 2023, the IQ consortium DMPK Guidelines for Targeted Covale

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