Design and Measurement of Drug Tissue Concentration Asymmetry and Tissue Exposure-Effect (Tissue PK-PD) Evaluation

已完结 10 由 musu 发布于 2026/5/6 14:30:35

DOI:10.1021/acs.jmedchem.2c00502
作者：Richard Zang*,?Aline Barth,?Harvey Wong,?Jan Marik,?Jie Shen,?Julie Lade,?Kerri Grove,?Matthew R. Durk,?Neil Parrott,?Patrick J. Rudewicz,?Sylvia Zhao,?Tao Wang,?Zhengyin Yan and Donglu Zhang*,?
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：The “free drug hypothesis” assumes that, in the absence of transporters, the steady state free plasma concentrations equal to that at the site of action that elicit pharmacologic effects. Wh

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