PI3K Regulates Wild-type RAS Signaling to Confer Resistance to KRAS Inhibition.

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DOI:10.1158/0008-5472.CAN-25-3625
作者：Xiangyu Ge,?Jaffarguriqbal Singh,?Wenxue Li,?Cassandra S Markham,?Christian Felipe Ruiz,?Edward C Stites,?Moitrayee Bhattacharyya,?Yansheng Liu,?Mandar Deepak Muzumdar
文献类型：期刊论文
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American Association for Cancer Research (AACR)

Abstract：Despite the availability of RAS inhibitors and the dependence of >90% of pancreatic ductal adenocarcinomas (PDAC) on oncogenic KRAS mutations, resistance to KRAS inhibition remains a serious

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